tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline → (S)-4,4-dimethylpyrrolidine-2-carboxylic acid

HRID 1295621Notes

Reaction equation

HRID 1295621 reaction equation
C([C@@:5]1([C:19]([OH:21])=[O:20])[CH2:9][C:8]([CH3:11])([CH3:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)(C)(C)C>ClCCl>[CH3:10][C:8]1([CH3:11])[CH2:7][NH:6][C@H:5]([C:19]([OH:21])=[O:20])[CH2:9]1

Participants

3

Reactant 1

HCID 67158944tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

Product 1

HCID 46907953(S)-4,4-dimethylpyrrolidine-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

Workup

  1. concentrationThe solution was concentrated
  2. customdried under high vacuum
  3. customtaken to the next step without further purification

Sources & evidence

ORD record
ord-ea5e0800c6514c9787779a78e4daabb6
Source dataset
uspto-grants-2007_07
Patent number
US07244721B2

Reaction notes

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