Methanol → HCID 21015967, compound

HRID 1295622Notes

Reaction equation

HRID 1295622 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:8][C:7]([CH3:10])([CH3:9])[CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].S(Cl)([Cl:20])=O.[CH3:22]O>>[ClH:20].[CH3:22][O:5][C:3](=[O:4])[C@@H:2]1[CH2:6][C:7]([CH3:10])([CH3:9])[CH2:8][NH:1]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 250673061-(tert-Butoxycarbonyl)-4,4-dimethyl-L-proline

Product 1

HCID 21015967HCID 21015967, compound

Procedure

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 l, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Workup

  1. concentrationThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Sources & evidence

ORD record
ord-521a57fb78104cc8bb2ab7fc9f9ebdb3
Source dataset
uspto-grants-2007_07
Patent number
US07244721B2

Reaction notes

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