HCID 11966965, compound → HCID 9803861, compound

Participants

Reaction Steps

A mixture of 1-butyl-2-{2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-biphenyl-4-yl(hydroxy)methyl}-1H-indole-3-carboxylic acid (2.5 g, 3.52 mmol) and 10% palladium on carbon (1.2 g) in 20 mL of acetic acid and 80 mL of THF under a hydrogen atmosphere (200 psi) at 48° C. for approximately 48 hours. The mixture was then cooled, filtered and diluted with 500 mL of water. The mixture was extracted with 100 mL of ethyl acetate and the ethyl acetate layer was washed three times with water. The ethyl acetate layer was concentrated to give 1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid (1.2 g, 2.66 mmol).

Provenance & Evidence