HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl cyanophosphonate → (4-Ethyl-piperazin-1-yl]-[4-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenyl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | 4-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-benzoic acid lithium salt | HCID 69180619 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Ethyl-piperazin-1-yl]-[4-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenyl]-methanone | HCID 10207082 | — |
Reaction Steps
To 340 mg (0.83 mMol) 4-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-benzoic acid lithium salt in 5 ml of DMF under N2 atmosphere, 0.38 ml (3 mMol) of N-ethylpiperazine and 0.31 ml (95%; 2 mMol) of diethyl-cyanphosphonate are added at 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244729B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-343585663e8243a1b77694b1d0bc0cee |
| Source note | uspto-grants-2007_07 |