反应详情

To a solution of NaOH (5.4 g, 125 mmol) in a mixture of water/DMSO (1:1; 15 mL) at 80° C. was added 1-(3-chloro-2-pyrazinyl)-4-methylpiperazine (obtained in Step 1 above; 2.5 g, 12 mmol). After being stirred for 2 h, the dark red solution was cooled to room temperature, extracted with EtOAc overnight to give, after drying and solvent removal in vacuo, 0.96 g (43%) of the title compound as an off-white solid. HPLC purity: 88%. MS m/z 195 (M+H)+. HRMS m/z calcd for C9H14N4O (M)+ 194.1168, found 194.1159.

1. extractionextracted with EtOAc overnight
2. customto give
3. customafter drying
4. customsolvent removal in vacuo, 0.96 g (43%) of the title compound as an off-white solid