Triphenylphosphine → HCID 86591620, compound

Participants

Reaction Steps

DEAD (0.520 ml, 3.3 mmol) was added to a slurry of 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy]ethanol (1.00 g, 3.08 mmol), 4-cyanophenol (0.381 g, 3.20 mmol) and resin bound triphenylphosphine (1.1 g, 3.3 mmol) in dichloromethane (10 mL) and shaken overnight. The reaction mixture was filtered, concentrated and purified by chromatography on silica gel using toluene/EtOAc (1:1) as eluent to give 0.168 g (13%) of the title compound. 1H NMR and MS analyses support the stated structure. HRMS m/z calcd for C22H27N5O4 (M)+ 425.2063, found 425.2075.

Provenance & Evidence