HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethyl bromide → 3-[4-(2-Phenylethyl)piperazin-1-yl-]1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | 2(1H)-Pyrazinone, 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]- | HCID 10405848 | — |
| Reactant | 3-(1-Piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone, Hydrochloride | HCID 11639709 | — |
| Product | 3-[4-(2-Phenylethyl)piperazin-1-yl-]1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one, Hydrochloride | HCID 10051451 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 60 starting from 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone (0.71 g, 2.0 mmol; from the free base of Example 3) and (2-bromoethyl)benzene (0.41 g, 2.2 mmol). Yield: 0.20 g (20%). HPLC purity: 96%. HRMS calc for C24H25F3N4O2 (M)+ 458.1930, found 458.1928.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244722B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-b5332316ce2f4ec6b0552eccf298c207 |
| Source note | uspto-grants-2007_07 |