3-Hydroxybenzaldehyde → 3-[(Methylsulfanyl)methoxy]benzaldehyde

Participants

Reaction Steps

3-Hydroxybenzaldehyde (6.106 g, 50.00 mmol) was dissolved in acetone at room temperature. K2CO3 (13.821 g, 100.00 mmol), NaI (7.569 g, 50.00 mmol) and chloromethyl methyl sulfide (4.19 mL, 50.00 mmol) were added, and the mixture was allowed to stir for 80 h. The mixture was filtered, the filtrate concentrated to an oil, and the residue purified by SiO2 eluted with 99:1 CH2Cl2/MeOH to give 3.309 g (36.31%) of a yellow oil.

Provenance & Evidence