Sodium borohydride → HCID 69507792, compound

HRID 1295737Notes

Reaction equation

HRID 1295737 reaction equation
[CH3:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1.[BH4-].[Na+]>CCO>[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 69507905828242-89-3

Product 1

HCID 69507792HCID 69507792, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

Compound from step 2 (3.546 g, 18.16 mmol) was dissolved in EtOH (50 mL) and cooled to 0° C. NaBH4 (859 mg, 22.70 mmol) was added and the mixture was allowed to stir for 4 h. The reaction was carefully quenched with water. The EtOH was removed in vacuo. The aqueous residue was extracted with CH2Cl2. The organic extracts were dried over Na2SO4 and concentrated in vacuo to give 2.044 g (57%) of a clear yellow oil.

Workup

  1. customThe reaction was carefully quenched with water
  2. customThe EtOH was removed in vacuo
  3. extractionThe aqueous residue was extracted with CH2Cl2
  4. dry with materialThe organic extracts were dried over Na2SO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6f44ce3d52c6454cadab13845d9096b1
Source dataset
uspto-grants-2007_07
Patent number
US07244738B2

Reaction notes

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