Sodium Cyanide → 114812-34-9

HRID 129575Notes

Reaction equation

HRID 129575 reaction equation
Cl.[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([O:11]C)=O)[CH3:3].[C-]#[N:14].[Na+]>N.CO>[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([NH2:14])=[O:11])[CH3:3]

Participants

5

Reactant 2

HCID 8929Sodium CyanideHCID 86747729methyl (S)-1-ethyl-2-pyrrolidinecarboxylate hydrochloride

Product 1

HCID 10866443114812-34-9Yield 632.9%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

Crude methyl (S)- 1-ethyl-2-pyrrolidinecarboxylate hydrochloride (2.1 g, 0.01 mol; Example 6A) and NaCN (50 mg, 0.001 mol) in 30 ml 9M NH3 in MeOH was heated to 45° C. in a sealed glass flask for 2 days. GLC showed a conversion of 95% and usual work-up afforded 0.9 g (63%) of the title compound.

Sources & evidence

ORD record
ord-561d4ad532d8459a9a9e9007085aa4ad
Source dataset
uspto-grants-1995_11
Patent number
US05468876

Reaction notes

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