Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 88638 | — |
| Reactant | 3-Oxazolidinesulfonamide, 2-oxo-N-(phenylmethyl)- | HCID 3088080 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 56876813 | HCID 56876813 | 11.3% |
Reaction Steps
2-Oxo-oxazolidine-3-sulfonic acid benzylamide (0.059 g; 0.23 mmol; 1 equiv) was added to a solution of 1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one (0.050 mg; 0.23 mmol) in acetonitrile (2 mL). Triethylamine (32 μL; 0.23 mmol) was added and the reaction mixture was heated at 80° C. for 48 h. The reaction mixture was evaporated under reduced pressure and the crude product was purified by preparative liquid chromatography to provide 4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-sulfonic acid benzylamide (0.010 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07244744B2 |
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| Source dataset | uspto-grants-2007_07 |
|---|
| ORD ID | ord-a4677949cbcd4d6ea000f78999e782e7 |
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| Source note | uspto-grants-2007_07 |
|---|
