HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → Methyl 2-aminothiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Methyl 2-chloro-3-oxopropanoate | HCID 14355182 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-aminothiazole-5-carboxylate | HCID 238005 | 44.2% |
Reaction Steps
A mixture of 2.4 g of 2-chloro-3-oxo-propionic acid methyl ester (7-2), water 20 ml and 1.75 g of thiourea was refluxed for 2 hours. The mixture was cooled to room temperature and 0.25 g of norit was added and filtered. A solution of 2.5N sodium hydroxide was added to the filtrate until neutral pH. The filtration yielded 1.23 g (44%) of 2-aminothiazole-5-carboxylic acid methyl ester (7-3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244752B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-55d79ec6003d4576af1134c6171b4265 |
| Source note | uspto-grants-2007_07 |