反应详情

After dissolving tert-butyl 5-cyano-2-ethoxy-4-methylbenzoate (8.91 g) in carbon tetrachloride, N-bromosuccinimide (6.6 g) and benzoyl peroxide (400 mg) were added and the mixture was heated to reflux for 3 hours. The reaction mixture was filtered and concentrated. The residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield a mixture of the title compound and tert-butyl 5-cyano-2-ethoxy-4-methylbenzoate (starting material) (8.80 g) as a white solid.

1. additionwere added
2. temperaturethe mixture was heated
3. temperatureto reflux for 3 hours
4. filtrationThe reaction mixture was filtered
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)
7. customto yield