HCID 22930026, compound → HCID 22929942, compound

Participants

Reaction Steps

After dissolving 3-fluoro-4,5-dimethoxyphthalonitrile (450 mg, 2.18 mmol) in ethanol (50 ml), platinum oxide (0.1 g) was added. Catalytic hydrogenating reduction was carried out for 3 days at normal temperature and pressure. The catalyst was removed by celite filtration, washing was performed with methanol, and the filtrate was concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (solvent: ethyl acetate:methanol:27% aqueous ammonia=3:1:0.1) to yield the title compound as a brown solid (200 mg, 43%).

Provenance & Evidence