Water → (E)-methyl 3-methoxy-2-(2-[3-carboxyphenoxy]phenyl)propenoate

Participants

Reaction Steps

To (E)-methyl 3-methoxy-2-(2-[3-hydroxymethylphenoxy]phenyl)propenoate (2.43 g, prepared as described in Example 17) stirred in acetone (100 ml) at 5°-10° C., was added chromic acid [made by dissolving chromium trioxide (6.5 g) in 18.5 ml water containing 5.5 ml of concentrated sulphuric acid] until a reddish brown colour persisted, and GC indicated the disappearance of all the starting alcohol. The mixture was then poured into water and extracted with ether. The ether extracts were washed with water, dried and evaporated to give (E)-methyl 3-methoxy -2-(2-[3-carboxyphenoxy]phenyl)propenoate as a pale yellow oil (2.495 g).

Provenance & Evidence