反应详情

After dissolving 4,5-diethoxy-3-fluorophthalonitrile (103 g) in ethyl acetate-ethanol-methanol (600 ml-600 ml-300 ml), platinum oxide (8 g) was added and the mixture was stirred at room temperature for 4 days under a hydrogen stream. The reaction mixture was filtered through celite, the organic layer was distilled off under reduced pressure and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (21 g) as yellow crystals.

1. additionwas added
2. filtrationThe reaction mixture was filtered through celite
3. distillationthe organic layer was distilled off under reduced pressure
4. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)