反应详情

After dissolving 1-[3-(tert-butyl)-4-methoxy-5-morpholinophenyl]-1-ethanone (9.5 g) in tetrahydrofuran (60 ml), triethylamine (13 ml) and tert-butyl dimethylsilyltrifluoromethanesulfonate (9.8 ml) were added dropwise while cooling on ice. The reaction mixture was stirred for 30 minutes while cooling on ice and then N-chlorosuccinimide (5.3 g) was gradually added. After continuing to stir the reaction mixture for 30 minutes, ether (2 l) was added thereto and the resulting mixture was washed twice with water. The organic layer was dried over anhydrous magnesium sulfate and then the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (4.87 g) as light yellow crystals.

1. additionwere added dropwise
2. temperaturewhile cooling on ice
3. temperaturewhile cooling on ice
4. stirringto stir the reaction mixture for 30 minutes
5. washthe resulting mixture was washed twice with water
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)