Acetyl chloride → 1-{4-[5-Bromo-3-(tert-butyl)-2-methoxyphenyl]piperazino}-1-ethanone

Participants

Reaction Steps

Acetyl chloride (0.10 ml) was mixed with a solution of 1-[5-bromo-3-(tert-butyl)-2-methoxyphenyl]piperazine (370 mg) and triethylamine (0.32 mL) in methylene chloride (8 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was diluted with ethyl acetate and, after filtering off the insoluble portion, was concentrated. The residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (338 mg) as colorless crystals (81%).

Provenance & Evidence