Triethylamine → HCID 58910055, compound

Participants

Reaction Steps

Methoxyacetyl chloride (0.28 ml) was added to a solution of 1-[5-bromo-3-(tert-butyl)-2-methoxyphenyl]piperazine (850 mg) and triethylamine (0.73 ml) in methylene chloride (12 ml) while cooling on ice, the mixture was brought to room temperature and stirred for 1 hour. The reaction mixture was diluted with ethyl acetate, the insoluble portion was filtered off, and the concentrated residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (730 mg) as light red crystals (70%).

Provenance & Evidence