Tetrahydrofuran → 3-ethoxy-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-7-amine

Participants

Reaction Steps

Triphenylphosphine (170 mg, 0.648 mmol) was added to a solution of the 3-(azidomethyl)-5-ethoxy-4,6-dimethyl-2-pyridinecarbonitrile (113 mg, 0.489 mmol) in a tetrahydrofuran (3 ml) —H2O (0.15 ml) mixed solvent while cooling on ice, and the mixture was stirred at room temperature for 2.5 hours. The solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography (solvent: ethyl acetate-methanol-29% NH3(aq)) to yield the title compound (69 mg, 69%) as a yellow solid.

Provenance & Evidence