1-[3-(tert-Butyl)-4-(methoxymethoxy)-5-nitrophenyl]-1-ethanone → 1-[3-Amino-5-(tert-butyl)-4-(methoxymethoxy)phenyl]-1-ethanone

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Reaction Steps

After adding 10% palladium-carbon (50% wet) (14 g) to a solution of the 1-[3-(tert-butyl)-4-(methoxymethoxy)-5-nitrophenyl]-1-ethanone (69.4 g, 247 mmol) in toluene (280 ml) at room temperature, the mixture was hydrogenated for 7 hours under normal pressure. The 10% palladium-carbon was removed by celite filtration and the solvent was distilled off under reduced pressure. The residue was recrystallized from hexane to yield the title compound (54.0 g, 87.1% yield) as light green granular crystals.

Provenance & Evidence