Toluene → HCID 137328926, compound

Participants

Reaction Conditions

Reaction Steps

After dissolving 1-(tert-butyl)-1,1-diphenylsilyl [(6-chloro-3-pyridyl)methyl]ether (20 g, 52.3 mmol) in toluene (104 ml) and degassing the solution, tetrakis(triphenylphosphine)palladium (3.0 g, 2.6 mmol) and tributylvinyltin (16.5 ml, 56.5 mmol) were added under a nitrogen stream and the mixture was heated to reflux at 120° C. for 7 hours. The reaction mixture was then cooled to room temperature and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (17.46 g) as a colorless oil. (89.3% yield)

Provenance & Evidence