Triphenylphosphine → HCID 22929954, compound

Participants

Reaction Steps

After dissolving 3-(azidomethyl)-6-ethyl-2-pyridinecarbonitrile (1.0 g, 5.34 mmol) in tetrahydrofuran (16 ml)-water (0.8 ml), triphenylphosphine (2.1 g, 8.01 mmol) was added while stirring on ice, and the mixture was further stirred at room temperature for 2.0 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (solvent: ethyl acetate, ethyl acetate:methanol=4:1, ethyl acetate:methanol:aqueous ammonia=2:1:0.1 in this order). The title compound (0.769 g) was obtained as a light green substance. (89.3% yield)

Provenance & Evidence