Tetrahydrofuran → HCID 22930006, compound

Participants

Reaction Steps

Triphenylphosphine (365 mg, 1.39 mmol) was added at room temperature to a solution of the 3-(azidomethyl)-6-cyclopropyl-2-pyridinecarbonitrile (230 mg, 1.15 mmol) in a tetrahydrofuran (4 ml) —H2O (0.2 ml) mixed solvent and the mixture was stirred for 3 hours. The solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography, to yield the title compound (180 mg, 90%) as a white amorphous solid from the ethyl acetate-methanol-29% NH3(aq) (30:10:1) elution fraction.

Provenance & Evidence