反应详情

温度

70 °C

Chloroacetyl chloride (0.14 ml, 1.76 mmol) was added at room temperature to a solution of the 1-[3-amino-5-(tert-butyl)-4-hydroxyphenyl]-1-ethanone (300 mg, 1.45 mmol) in a methylene chloride (3 ml)-saturated aqueous sodium hydrogencarbonate (3 ml) mixed solvent, and the resultant mixture was stirred for 30 minutes. After adding ethyl acetate to the reaction mixture for separation, the organic layer was washed with brine. After drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The residue was dissolved in dimethylformamide (6 ml), potassium carbonate (401 mg, 2.90 mmol) was added and the mixture was stirred at 70° C. for 7 hours under a nitrogen atmosphere. The solvent was distilled off under reduced pressure, and then ethyl acetate was added to the residue and the mixture was washed with water and brine in that order. After drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The residue was subjected to silica gel chromatography (Wakogel-C200,7 g), and the fraction containing the target compound was obtained from the ethyl acetate-toluene (1:9˜1:6) fractions and crystallized from diethyl ether-diisopropyl ether to yield the title compound (102 mg, 28.5% yield) as yellow ochre crystals.

1. additionmixed solvent
2. customfor separation
3. washthe organic layer was washed with brine
4. dry with materialAfter drying over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. dissolutionThe residue was dissolved in dimethylformamide (6 ml)
7. distillationThe solvent was distilled off under reduced pressure
8. additionethyl acetate was added to the residue
9. washthe mixture was washed with water and brine in that order
10. dry with materialAfter drying over anhydrous magnesium sulfate
11. distillationthe solvent was distilled off under reduced pressure
12. additionthe fraction containing the target compound
13. customwas obtained from the ethyl acetate-toluene (1:9˜1:6) fractions
14. customcrystallized from diethyl ether-diisopropyl ether