Iodoethane → HCID 22929833, compound

Participants

Reaction Steps

Cesium carbonate (10.05 g, 30.9 mmol) and EtI (2.58 ml, 32.2 mmol) were added to a solution of the 5-bromo-3-(tert-butyl)-2-(methoxymethoxy)phenol (7.76 g, 26.8 mmol) in acetonitrile and the mixture was stirred at room temperature for 3 hours. Ethyl acetate was added and the reaction mixture was washed with water and brine in that order. The organic layer was dried over anhydrous magnesium sulfate and then the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (6.5 g) as a yellow oil.

Provenance & Evidence