Thiophenol → HCID 58909955, compound

Participants

Reaction Steps

After dissolving thiophenol (1.27 ml) in dimethylformamide (20 ml), sodium hydride (480 mg) was added. The mixture was stirred at room temperature for 30 minutes and then the N1-methyl-5-bromo-4-({{2-[3,5-di(tert-butyl)-4-hydroxyphenyl]-2-oxoethyl}[(4-nitrophenyl)sulfonyl]amino}methyl)-2-ethoxybenzamide (2.95 g) was added. After stirring at room temperature for 1 hour, the mixture was diluted with ethyl acetate and washed with water and brine, and then the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (1.75 g) as a light orange oil. (78% yield)

Provenance & Evidence