Tert-butyldicarbonate → HCID 58910006, compound

Participants

Reaction Steps

After dissolving the N1-methyl-5-bromo-4-[({2-[3,5-di(tert-butyl)-4-hydroxyphenyl]-2-oxoethyl}amino)methyl]-2-ethoxybenzamide (1.75 g) in tetrahydrofuran (20 ml), tert-butyl dicarbonate (770 mg) was added. The mixture was heated to reflux for 2 hours, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (1.97 g) as a white solid.

Provenance & Evidence