反应详情

A solution of 13A (14.1 g, 49.4 mmol) in 3:1 THF/MeOH, was treated with NaBH4 (5.6 g, 148 mmol) at ambient temperature. The reaction was then stired for 3H, followed by concentrating in vacuo to about 50 mL, quenching with 2 M HCl, extract 1×150 mL EtOAC, dry (Na2SO4) and concentrate in vacuo to give 11.8 g of the title compound pure enough for subsequent use. MS m/z 244 (M+1).

1. concentrationby concentrating in vacuo to about 50 mL
2. customquenching with 2 M HCl
3. extractionextract 1×150 mL EtOAC
4. dry with materialdry (Na2SO4)
5. concentrationconcentrate in vacuo