反应详情

温度

90 °C

1-Bromo-4-trifluoromethyl-benzene (814 mg, 3.62 mmol), 4-hydroxymethylphenylboronic acid (600 mg, 3.98 mmol), cesium carbonate (2.36 g, 7.24 mmol), and PdCl2(dppf) (132 mg, 0.181 mmol) were added to 10 ml of a 1:1 solution of DMF/THF. The reaction was flushed with nitrogen and heated to 90° C. for 1 h. The reaction was cooled, poured into diethyl ether and washed with water (2×50 ml), brine (1×50 ml) and dried over anhydrous sodium sulfate. The crude product was filtered through silica gel, eluted with diethyl ether, and concentrated to provide the title compound. MS m/z 251 (M−1).

1. customThe reaction was flushed with nitrogen
2. temperatureThe reaction was cooled
3. additionpoured into diethyl ether
4. washwashed with water (2×50 ml), brine (1×50 ml)
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationThe crude product was filtered through silica gel
7. washeluted with diethyl ether
8. concentrationconcentrated