Lithium Hydroxide → HCID 22504899, compound

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Reaction Steps

The title compound was prepared in the manner analogous to example 24 using {6-[5-(4-trifluoromethyl-phenyl)-isoxazol-3-ylmethoxy]-benzofuran-3-yl}-acetic acid methyl ester (80A) and lithium hydroxide. mp 201° C. (decompose); IR (thin film) cm−1: 1711, 1600, 1433, 1319, 1228, 1143; 400 MHz 1H NMR (DMSO-d6) 12.40 (br s, 1H), 8.08 (d, 2H, J=8.1 Hz), 7.86 (d, 2H, J=8.1 Hz), 7.74 (s, 1H), 7.45 (d, 1H, J=8.6. Hz), 7.35 (s, 1H), 7.30 (d, 1H, J=2.0 Hz), 6.93 (dd, 1H, J=6.3, 2.2 Hz), 5.27 (s, 2H), 3.60 (s, 2H); MS m/z 416 (M−1). Anal. Calc'd for C21H14F3NO5: C, 60.44; H, 3.38; N, 3.36; found: 60.49; H, 3.23; N, 3.34.

Provenance & Evidence