HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 129616Generated: October 27, 2026
Triethylamine → Ethyl 4-[2-(4,4-dibutylthiochroman-6-yl)-ethyn-1-yl]benzoate
https://huagongshe.com/reaction/129616
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl6-iodonicotinoate | HCID 10891136 | — |
| Reactant | (4,4-Dibutylthiochroman-6-yl)acetylene | HCID 15895302 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | Ethyl 4-[2-(4,4-dibutylthiochroman-6-yl)-ethyn-1-yl]benzoate | HCID 15296880 | — |
Reaction Steps
A mixture of 0.234 g (0.82 mmol) of (4,4-dibutylthiochroman-6-yl)acetylene (Compound 35), 21 mg (0.11 mmol) of copper (I) iodide, and 1.45 g (14 mmol) of triethylamine were degassed with argon for 15 min. To the suspension was added 0.49 g (1.8 mmol) of ethyl 4-iodobenzoate (Compound 21) and then 0.065 g (0.09 mmol) of bis(triphenyliphosphine)palladium (II) chloride. The suspension was degassed with argon for an additional 5 minutes, the tube was sealed and the mixture stirred at 55° C. for 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05468879 |
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| Source dataset | uspto-grants-1995_11 |
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| ORD ID | ord-e69551b5fcd0496aa84a521baa3d08a8 |
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| Source note | uspto-grants-1995_11 |
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