Water → HCID 67655879, compound

HRID 129617Notes

Reaction equation

HRID 129617 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])=[CH:5][CH:4]=1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O>C1(C)C=CC=CC=1>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][C:9](=[CH:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH3:20]

Participants

5

Reactant 3

HCID 962WaterHCID 695242,2-DiethoxyethylamineHCID 10085154HCID 10085154, compound

Product 1

HCID 67655879HCID 67655879, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4'-methoxy-2-[(trifluoromethyl)sulfonyl]acetophenone (6.0 g, 0.021 mol) in toluene is treated with aminoacetaldehyde diethyl acetal (2.8 g, 0.021 mol), heated at reflux overnight with removal of water, and concentrated in vacuo to obtain the title product as an oil. This oil is used in Example 4 without further purification.

Workup

  1. temperatureheated
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b6ce6266caf546e1acb447fab0ed05e9
Source dataset
uspto-grants-1995_11
Patent number
US05468877

Reaction notes

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