反应详情

2-Amino-1,3-dihydroxypropane (27.4 g, 300 mmol) and 1.5M solution of sodium methylate in methanol (14.3 mL, 21.5 mmol) are added to a suspension of 5-amino-1,3-benzenedicarboxylic acid dimethyl ester (30.0 g, 143 mmol) in methanol (0.2 L). The reaction mixture is heated to the reflux temperature to get a solution. After 2.5 hours of reflux and 4 hours at room temperature the reaction mixture is filtered and the solid on filter is washed with methanol (40 mL) and dried yielding the product of the title (43.5 g, 133 mmol, yield: 93%).

1. temperatureThe reaction mixture is heated to the reflux temperature
2. customto get a solution
3. filtrationis filtered
4. filtrationthe solid on filter
5. washis washed with methanol (40 mL)
6. customdried
7. customyielding the product of the title (43.5 g, 133 mmol, yield: 93%)