反应详情

温度

70 °C

A mixture of 2-amino-1,3-dihydroxypropane (31 g, 340 mmol) and 5-amino-1,3-benzenedicarboxylic acid di-n-butyl ester (20.0 g, 68.2 mmol) is heated to 125° C. for 3 hours while the n-butyl alcohol which forms is distilled off. After cooling the reaction mixture to about 70° C. the solution is diluted with methanol (0.35 L) and a solid product crystallizes out. After 4 hours at room temperature the mixture is filtered and the solid on filter is washed with methanol (30 mL) and dried yielding the compound of the title (21.4 g, 65.5 mmol, yield: 96%).

1. distillationforms is distilled off
2. additionis diluted with methanol (0.35 L)
3. customa solid product crystallizes out
4. filtrationAfter 4 hours at room temperature the mixture is filtered
5. filtrationthe solid on filter
6. washis washed with methanol (30 mL)
7. customdried
8. customyielding the compound of the title (21.4 g, 65.5 mmol, yield: 96%)