Hydrochloric Acid → HCID 11383152, compound

Participants

Reaction Steps

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-bromo-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one from Step A (105 mg, 0.24 mmol) was added diethyl ether (2 nL) and saturated aqueous hydrochloric acid (1 mL). After 15 min of stirring, the reaction was concentrated and treated with saturated aqueous ammonium hydroxide (2 nL). The solution was concentrated to dryness and the resulting residue was purified by radial chromatography (2% ammonium hydroxide in 4% methanol in dichloromethane) to give a clear residue. The residue was treated with 1N aqueous hydrogen chloride and lyophilized to afford the desired product (33 mg, 37%) as an off-white solid. MS (ESI) 335.2, 337.2 (M−Cl).

Provenance & Evidence