Hydrochloric Acid → HCID 11175785, compound

Participants

Reaction Steps

A stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(2-furyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (44 mg, 0.10 mmol) in diethyl ether (2 mL) was treated with concentrated aqueous hydrogen chloride (1 mL). The resulting mixture was stirred vigorously for 15 min and was then concentrated. Saturated aqueous ammonium hydroxide (2 mL) was added, and the white mixture was concentrated. The resulting residue was purified by radial chromatography (2% ammonium hydroxide in 8% methanol in dichloromethane); the product was then treated with aqueous hydrogen chloride (1N) and lyophilized to give the desired hydrochloric acid salt as a white solid (28 mg, 68%). MS (ESI) 323.3 (M−Cl).

Provenance & Evidence