Pyridine → HCID 68688953, compound

Participants

Reaction Steps

Pyridine (0.57 ml, 7.0 mmol) was added to a stirring solution of (2S,5R)-1,5-dibenzyl-2-methylpiperazine (0.40 g, 1.2 mmol) and methyl chloroformate (0.20 ml, 2.5 mmol) in CH2Cl2 (14 ml). After stirring at ambient temperature for 2 h, the reaction was evaporated in vacuo and the residue purified by flash chromatography (SiO2, 3% MeOH in CH2Cl2) to afford pure product (0.28 g, 68% yield over the two steps). MS (ESI) 339 (M+H).

Provenance & Evidence