Methanol → HCID 68687822, compound

Participants

Reaction Steps

Cesium carbonate (0.18 g) was added to a solution of N-(2,4-dimethoxybenzyl)-2-chloro-N-(((3R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)propanamide (0.18 g, 0.44 mmol) in DMF (4.7 ml). After stirring at ambient temperature for 3 h, the reaction was transferred to a separatory funnel with EtOAc. Extraction with EtOAc, washing the organic layer with water (3×) and brine and drying over MgSO4 afforded 0.15 g of crude product. Flash chromatography (SiO2, 0.2 to 10% MeOH in CH2Cl2) gave pure product (0.11 g, 68%). MS (ESI) 367 (M+H).

Provenance & Evidence