Tributylvinyltin → HCID 68692187, compound

Participants

Reaction Conditions

Reaction Steps

Degassed mixture of (R)-2-Benzyl-8-methyl-1,2,3,4,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-6-one (50 mg, 0.13 mmol), tributyl(vinyl)tin (64 mg, 0.20 mmol), dichlorobis(triphenylphosphine)palladium (9.1 mg, 0.013 mmol) and LiCl (27.5 mg, 0.65 mmol) in toluene (1 mL) was heated at 110° C. for 18 h to give dark brownish reaction mixture. The mixture was then cooled, diluted with ethyl acetate(10 mL) and filtered through bed of celite and rinsed with more ethyl acetate(20 mL). Filtrate was concentrated and purified by prep TLC (SiO2, 95:5, CH2Cl2:MeOH) to give (25 mg, 60%) as a faint yellow oil. MS (ESI) 319 (M+H).

Provenance & Evidence