Proton sponge → HCID 69416303, compound

Participants

Reaction Steps

The solution of 4-benzyl-2-[5-(4-chlorophenyl)-1-(2-chlorophenyl)-4-methyl-1H-pyrazol-3-yl]-morpholine 5A-1 (840 mg, 1.7 mmol), 1-chloroethyl chloroformate (0.2 ml, 1.87 mmol), and 1,8-bis(dimethylamino)naphthalene (72 mg, 0.34 mmol) in 5 ml 1,2-dichloroethane was heated to 50° C. for 3 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The residue was dissolved in 5 ml MeOH and heated to reflux for 2 hours. After the reaction was completed, the reaction mixture was cooled to room temperature and concentrated. The residue was stirred in 5 ml diethyl ether and the product was precipitated and collected by filtration to give the title compound 5A-2 as a white solid (525 mg).

Provenance & Evidence