Morpholine → HCID 69417426, compound

Participants

Reaction Steps

Morpholine (0.04 ml, 0.426 mmol) was added to a solution of 2-bromo-1-[1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-ethanone I-7g (63 mg, 0.142 mmol) in THF (3 ml). The resultant solution was stirred at 23° C. for 12 hours, diluted with 50 ml methyl tert-butyl ether, and washed with 25 ml water. The organic phase was dried over anhydrous magnesium sulfate and concentrated. The residue was co-evaporated with hexanes once to afford 1-[1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazol-4-yl]-2-morpholin-4-yl-ethanone 7A-1 (52 mg, 81%) as a solid.

Provenance & Evidence