HCID 12070472, compound → HCID 12070473, compound

HRID 1296374Notes

Reaction equation

HRID 1296374 reaction equation
[H][H].[C:3]([O:6][C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][C:9]([N+:17]([O-])=O)([CH2:10]3)[CH2:8]1)[CH2:14]2)(=[O:5])[CH3:4]>>[C:3]([O:6][C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][C:9]([NH2:17])([CH2:10]3)[CH2:8]1)[CH2:14]2)(=[O:5])[CH3:4]

Participants

3

Reactant 2

HCID 12070472HCID 12070472, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12070473HCID 12070473, compoundYield 70%

Procedure

An autoclave was charged, 10 mmole of 1-acetyloxy-3-nitroadamantane obtained by the method of Example 14, 5% Pd-C (10 mole % of Pd relative to a substrate), 1 ml of dilute hydrochloric acid and 10 ml of methanol. The mixture was stirred for 2 hours at 80° C. in an atmosphere of hydrogen at 30 atm. As a result, the conversion of 1-acetyloxy-3-nitroadamantane was 90%, and 1-acetyloxy-3-aminoadamantane (yield 70%) was formed.

Sources & evidence

ORD record
ord-62462b1dea9a4ff0814ac900a768d06f
Source dataset
uspto-grants-2007_07
Patent number
USRE039744E1

Reaction notes

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