Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 69153971 | HCID 69153971 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69154699 | HCID 69154699 | 86.1% |
Reaction Steps
To a stirring slurry of (R)-7-ethoxymethyl-8-(2-chloroethylsulfanyl)-1-(5-hydroxyhexyl)-3-methylxanthine (150 mg, 0.322 mmol) in ethanol (9.0 ml) was added concentrated hydrochloric acid (1.0 ml). After stirring at 80° C. for 3 hours and concentrating under reduced pressure, (R)-8-(2-chloroethylsulfanyl)-1-(5-hydroxyhexyl)-3-methylxanthine (100 mg, 86% yield) was obtained as a beige powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07247630B2 |
|---|
| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-c6da361d71f84b31914e67e6554f08f9 |
|---|
| Source note | uspto-grants-2007_07 |
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