HCID 69155336, compound → HCID 10149768, compound

HRID 1296424Notes

Reaction equation

HRID 1296424 reaction equation
C(O[CH2:4][N:5]1[C:9]2=[N:10][C:11]3[N:12]([CH3:26])[C:13](=[O:25])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][C@H:22]([OH:24])[CH3:23])[C:15](=[O:17])[C:16]=3[N:8]2[CH2:7][CH2:6]1)C.[H][H]>[Pd].C(O)(=O)C>[CH3:26][N:12]1[C:11]2[N:10]=[C:9]3[N:5]([CH3:4])[CH2:6][CH2:7][N:8]3[C:16]=2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][C@H:22]([OH:24])[CH3:23])[C:13]1=[O:25]

Participants

5

Reactant 2

HCID 69155336HCID 69155336, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10149768HCID 10149768, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of (R)-7,8-dihydro-8-ethoxymethyl-3-(5-hydroxyhexyl)-1-methyl-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (60 mg, 0.164 mmol) and 10% palladium on carbon (50% water, 100 mg) in acetic acid (25 ml) was treated with hydrogen gas (50 psi) on a Parr sharker at room temperature for 18 hours. After filtration through a pad of celite, concentration of the filtrate under reduced pressure provided (R)-7,8-dihydro-1,8-dimethyl-3-(5-hydroxyhexyl)-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (CT-31878) as a white powder.

Workup

  1. filtrationAfter filtration through a pad of celite, concentration of the filtrate under reduced pressure

Sources & evidence

ORD record
ord-7d461a3bf0fd442db7e19210f86c721a
Source dataset
uspto-grants-2007_07
Patent number
US07247630B2

Reaction notes

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