Ammonium Chloride → HCID 22288397, compound

HRID 1296471Notes

Reaction equation

HRID 1296471 reaction equation
[Cl-].[NH4+].[N+:3]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][C:14]([C:21]([F:24])([F:23])[F:22])=[N:13]2)=[CH:8][CH:7]=1)([O-])=[O:4]>[Zn].C(O)C>[OH:4][NH:3][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16]([C:17]([F:18])([F:19])[F:20])=[CH:15][C:14]([C:21]([F:24])([F:22])[F:23])=[N:13]2)=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 2781579HCID 2781579, compound

Product 1

HCID 22288397HCID 22288397, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 702EthanolSolvent

Procedure

Zinc powder and ammonium chloride were added to an aqueous ethanol solution of 1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole under ice-cooling, followed by stirring at 20° C. or below for 30 minutes. The insoluble matter in the reaction solution was removed by celite filtration, and then the filtrate was treated in the usual way to give 1-(4-hydroxyaminophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole as a colorless solid.

Workup

  1. temperaturecooling
  2. customThe insoluble matter in the reaction solution was removed by celite filtration
  3. additionthe filtrate was treated in the usual way

Sources & evidence

ORD record
ord-eb1c0f821f5f4d63beea16d06cf4f58e
Source dataset
uspto-grants-2007_07
Patent number
US07247635B2

Reaction notes

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