(3-Acetyl-4-fluorophenyl)boronic acid → HCID 11773097, compound

HRID 1296497Notes

Reaction equation

HRID 1296497 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([CH2:15][CH3:16])([CH2:13][CH3:14])[C:6]=2[CH:17]=1.[C:18]([C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][C:26]=1[F:27])(=[O:20])[CH3:19]>>[C:18]([C:21]1[CH:22]=[C:23]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([CH2:15][CH3:16])([CH2:13][CH3:14])[C:6]=3[CH:17]=2)[CH:24]=[CH:25][C:26]=1[F:27])(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 54758867(3-Acetyl-4-fluorophenyl)boronic acidHCID 692163266-amino-4,4-diethyl-1-methyl-1,4-dihydro-2H-3,1-benzoxazin-2-one

Product 1

HCID 11773097HCID 11773097, compound

Procedure

Prepared from 6-amino-4,4-diethyl-1-methyl-1,4-dihydro-2H-3,1-benzoxazin-2-one and 3-acetyl-4-fluorophenylboronic acid according to the coupling procedure described in example 1. MS (ESI) m/z 371 ([M+H]+); MS (ESI) m/z 369 ([M−H]−); High Resolution Mass Spectrometry (HRMS): calcd for C21H23FN2O3, 370.1693; found (ESI+), 371.17619; Anal. calcd for C21H23FN2O3: C, 68.09; H, 6.26; N, 7.56. Found: C, 67.36; H, 6.45; N, 7.65.

Sources & evidence

ORD record
ord-b58ae05cf8364e98bd9fc092d21cff22
Source dataset
uspto-grants-2007_07
Patent number
US07247625B2

Reaction notes

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