(4-Bromophenyl)boronic acid → HCID 69214092, compound

HRID 1296512Notes

Reaction equation

HRID 1296512 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([CH2:18][CH3:19])([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)[C:6]=2[CH:20]=1.[Br:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1>>[Br:21][C:22]1[CH:27]=[CH:26][C:25]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([CH2:18][CH3:19])([C:13]4[S:14][CH:15]=[CH:16][CH:17]=4)[C:6]=3[CH:20]=2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 79599(4-Bromophenyl)boronic acidHCID 69216580HCID 69216580, compound

Product 1

HCID 69214092HCID 69214092, compound

Procedure

Prepared 6-amino-4-ethyl-1-methyl-4-thien-2-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one and 4-bromophenyl boronic acid according to the coupling procedure described in Example 1. MS (ESI) m/z 443/445 ([M+H]+); MS (ESI) m/z 441/443 ([M−H]−); Anal. calcd for C21H19BrN2O2S: C, 56.89; H 4.32; N 6.32. Found: C, 56.65; H, 4.09; N, 6.18.

Sources & evidence

ORD record
ord-3ec8f4a31bb1401a82061be33d27ebf7
Source dataset
uspto-grants-2007_07
Patent number
US07247625B2

Reaction notes

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