Thionyl Chloride → HCID 178445070, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.5 g (8.4 mmol) of 6-[2-(1H-Tetrazol-5-yl)-ethyl]-decahydro-isoquinoline-3-carboxylic acid monohydrate (prepared as described in J. Med. Chem., 39 (11), pp. 2232-2244, (1996) or U.S. Pat. No. 5,670,516 (issued Sep. 23, 1997)) in 20 ml of 2-ethyl-1-butanol, 6.8 ml (92.8 mmol) of thionyl chloride is added. The solution is stirred at 120° C. for 3 hr. The mixture is concentrated in vacuo and the residue washed with ethyl ether. The residue is purified by SPE (Oasis HLB) to afford the title compound.

Provenance & Evidence