反应详情

温度

40 °C

22.2 g (or 0.057 mol) of hydroxy-tosyloxyiodobenzene, 9 g (or 0.04 mol) of n-octyl phenyl ether, 5 ml of acetonitrile and 1.5 ml of acetic acid were charged into a 250 ml Erlenmeyer flask equipped with a magnetic stirrer bar. This mixture was stirred and was heated to a temperature of 40° C. for 2 hours, 30 minutes. 1.5 ml of glacial acetic acid was then added and the mixture was then maintained for 5 hours at 40° C. The reaction mixture was permitted to cool and 150 ml of water were added while stirring vigorously. This mixture was then stirred for 12 hours at room temperature and was then separated. The organic phase was washed several times with water, until a yellow precipitate appeared. This solid was recovered by filtration, was washed with 50 ml of ether and was then dried under vacuum at a temperature of 45° C.

1. customequipped with a magnetic stirrer bar
2. temperaturethe mixture was then maintained for 5 hours at 40° C
3. temperatureto cool
4. stirringwhile stirring vigorously
5. stirringThis mixture was then stirred for 12 hours at room temperature
6. customwas then separated
7. washThe organic phase was washed several times with water
8. filtrationThis solid was recovered by filtration
9. washwas washed with 50 ml of ether
10. customwas then dried under vacuum at a temperature of 45° C.